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More Risk Than Benefit to Replacing Hormones PDF Print E-mail
Written by Dr. David Lipschitz   
Thursday, 21 June 2012 02:48

For many years, the use of hormone replacement therapy after menopause in women was felt to be invaluable in preventing disease and slowing the aging process -- allowing women to remain forever young. In those days, virtually every one received hormone replacement. In the field of geriatrics, it was not uncommon to initiate hormone replacement therapy in women beyond the age of 70, based on the common belief that heart disease would be prevented and memory loss slowed.

Then came a landmark study from the Women's Health Initiative comparing hormone replacement therapy to a placebo (sugar pills). Women who had undergone a hysterectomy received estrogen alone. Those with a uterus received estrogen plus progesterone. The trial was abruptly discontinued because of the high risk of breast cancer, strokes, heart disease and venous blood clots.

Since this report, published more than a decade ago, there has been a decline in the incidence and deaths from breast cancer, ascribed to fewer women receiving hormone replacement.

And today hormone replacement is virtually never prescribed initially in late life.

Despite this information, many experts believe that hormone replacement therapy is valuable. They belong to a group of "antiaging" experts who maintain that to be effective, hormone replacement must be individualized and tailored to the unique physiology of the individual woman. They are convinced that continued use of hormone replacement truly retards the aging process, promotes more vibrant skin, reduces wrinkles and assures a better sex life. However, the vast majority of the health care community does not share this point of view.

Nevertheless, their position has been bolstered somewhat by the fact that hormone replacement is effective in treating osteoporosis, while other commonly used medications to build bone and prevent fractures -- bisphosphonates -- are not without significant side effects.

Some evidence suggests that most of the adverse effects of hormone replacement therapy are due to progesterone. For women who are able to take estrogen treatment alone, the risks of breast cancer and heart disease are much lower.

While there is no question that hormone replacement therapy should be used for postmenopausal women who have symptoms such as hot flashes, mood disorders and headaches, their use to treat chronic conditions such as osteoporosis still remains questionable. To address this problem, the U.S. Preventive Services Task Force has just issued a recommendation, published in Annals of Internal Medicine, that hormone replacement therapy should not be used to treat any chronic condition, including osteoporosis.

In this report, the task force notes that combined estrogenprogesterone therapy does reduce the risk of fractures in postmenopausal women and may lower the risk of diabetes. They also note that estrogen treatment alone reduces fracture risk, decreases the risk of the more dangerous invasive breast cancer and even reduces the risk of breast-cancer death.

Despite these benefits, the task force strongly recommends against the use of hormone replacement therapy. They note that women taking estrogen and progesterone therapy have a higher risk of invasive breast cancer and deaths from breast cancer.

These women are more prone to have strokes, blood clots in the legs and lungs, gall bladder disease, memory loss, urinary incontinence and deaths from lung cancer. Migraines and heart attacks also are more prevalent.

And estrogen therapy alone is not safe. Strokes, blood clots in the legs and lung, gall bladder disease and urinary incontinence are frequent side effects.

Based on all these facts, most experts believe that hormone replacement therapy should be limited exclusively to women who have symptoms after menopause.

The lowest dose of hormones needed to relieve symptoms should be prescribed and treatment should be continued for as short a period of time as possible.

After menopause, women are more likely to develop chronic disease such as osteoporosis, diabetes, hypertension and heart disease. Every woman should be appropriately screened for these disorders. When needed, highly effective and relatively safe medications are available.

Sadly, there is no "fountain of youth," and aging is inevitable and normal. To date, neither hormone replacement therapy nor any other medication can make us either feel or be younger.

Dr. David Lipschitz is the author of the book "Breaking the Rules of Aging." More information is available at: